Shirdi Pharmaceuticals

Anastrozole Tablets IP are a medication used primarily for the treatment of breast cancer in postmenopausal women. Here’s a detailed overview:

1. Breast Cancer Treatment:

   • Anastrozole is used as an adjuvant treatment for hormone receptor-positive breast cancer.
   • It can be used as a first-line treatment for locally advanced or metastatic breast cancer.

2. Mechanism of Action:

   • Anastrozole is an aromatase inhibitor. It works by decreasing the amount of estrogen the body makes, which can slow or stop the growth of some breast cancer cells that need estrogen to grow.

• Standard Dosage:
  • The usual dosage is 1 mg taken once daily.
• Administration:
  • It can be taken with or without food.
  • It is usually taken for several years as prescribed by a healthcare provider.

• Common Side Effects:

  • Hot flashes
  • Joint pain or stiffness
  • Weakness
  • Sore throat
  • Nausea
  • Vomiting
  • Osteoporosis (long-term use)

• Serious Side Effects:

  • Chest pain
  • Shortness of breath
  • Severe skin reactions
  • Swelling of hands, feet, ankles, or lower legs

• Allergies:
  • Inform your doctor if you are allergic to anastrozole or any other medications.
• Medical History:
  • Disclose your medical history, especially of heart disease, osteoporosis, high cholesterol, or liver disease.
• Pregnancy and Breastfeeding:
  • Anastrozole should not be used during pregnancy or breastfeeding.

• Inform your doctor about all other medications you are taking, including prescription, over-the-counter, vitamins, and herbal supplements, to avoid potential interactions.

• Regular monitoring of bone density and cholesterol levels may be necessary while taking anastrozole due to the risk of osteoporosis and changes in cholesterol levels.

• Store at room temperature away from moisture, heat, and light.

Anastrozole Tablets IP are a medication used primarily for the treatment of breast cancer in postmenopausal women. Here’s a detailed overview:

1. Breast Cancer Treatment:

   • Anastrozole is used as an adjuvant treatment for hormone receptor-positive breast cancer.
   • It can be used as a first-line treatment for locally advanced or metastatic breast cancer.

2. Mechanism of Action:

   • Anastrozole is an aromatase inhibitor. It works by decreasing the amount of estrogen the body makes, which can slow or stop the growth of some breast cancer cells that need estrogen to grow.

• Standard Dosage:
  • The usual dosage is 1 mg taken once daily.
• Administration:
  • It can be taken with or without food.
  • It is usually taken for several years as prescribed by a healthcare provider.

• Common Side Effects:

  • Hot flashes
  • Joint pain or stiffness
  • Weakness
  • Sore throat
  • Nausea
  • Vomiting
  • Osteoporosis (long-term use)

• Serious Side Effects:

  • Chest pain
  • Shortness of breath
  • Severe skin reactions
  • Swelling of hands, feet, ankles, or lower legs

• Allergies:
  • Inform your doctor if you are allergic to anastrozole or any other medications.
• Medical History:
  • Disclose your medical history, especially of heart disease, osteoporosis, high cholesterol, or liver disease.
• Pregnancy and Breastfeeding:
  • Anastrozole should not be used during pregnancy or breastfeeding.

• Inform your doctor about all other medications you are taking, including prescription, over-the-counter, vitamins, and herbal supplements, to avoid potential interactions.

• Regular monitoring of bone density and cholesterol levels may be necessary while taking anastrozole due to the risk of osteoporosis and changes in cholesterol levels.

• Store at room temperature away from moisture, heat, and light.

Bevacizumab (brand name Avastin) is a monoclonal antibody used in the treatment of various cancers. It works by inhibiting vascular endothelial growth factor (VEGF), a protein that promotes the growth of new blood vessels (angiogenesis) that tumors need to grow and spread.

Here’s a detailed overview of Bevacizumab injection:

• Strength: 400 mg per vial
• Presentation: Solution for intravenous (IV) infusion.

Bevacizumab is used to treat several types of cancer, including:

• Colorectal Cancer: Often used in combination with chemotherapy for advanced or metastatic disease.
• Non-Small Cell Lung Cancer (NSCLC): For metastatic NSCLC, often used with chemotherapy.
• Renal Cell Carcinoma: Used with interferon alfa for advanced renal cell carcinoma.
• Ovarian Cancer: Used in combination with chemotherapy for advanced disease.
• Glioblastoma: Used in combination with other treatments for glioblastoma, a type of brain tumor.

• Dosage: The specific dosage and schedule depend on the type of cancer being treated and the patient’s overall health. Typically, the initial dose is 5 mg/kg or 10 mg/kg depending on the condition, administered every two or three weeks.
• Infusion: Administered via intravenous infusion. The infusion is typically given over a period of 30 to 90 minutes, depending on the dose and the patient’s reaction.

Common side effects include:

• Fatigue
• Hypertension (high blood pressure)
• Gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea)
• Mouth sores
• Loss of appetite

Serious side effects can include:

• Bleeding: Gastrointestinal bleeding or bleeding in the brain.
• Wound Healing Problems: Delayed wound healing or surgical wound complications.
• Thromboembolic Events: Blood clots in veins or arteries.
• Proteinuria: High levels of protein in the urine, which can indicate kidney issues.

• Blood Pressure: Monitor and manage blood pressure regularly, as bevacizumab can cause or worsen hypertension.
• Wound Healing: Be cautious with surgery or wounds; bevacizumab can impair wound healing.
• Bleeding Risk: Watch for signs of bleeding or unusual bruising.
• Proteinuria: Regular urine tests may be needed to monitor for protein in the urine.

• Before Use: Store in the refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze.
• After Reconstitution: The solution should be used immediately or as per the manufacturer’s instructions if stored.

Tenofovir Disoproxil Fumarate (TDF) is an antiviral medication used primarily in the treatment of HIV (human immunodeficiency virus) infection and chronic hepatitis B virus (HBV) infection. The "Tenofovir Disoproxil Fumarate Tablets IP 300 mg" indicates that each tablet contains 300 milligrams of tenofovir disoproxil fumarate and conforms to the standards set by the Indian Pharmacopoeia (IP).

• Form: Oral tablets.
• Dosage: 300 mg per tablet.
• Use:
  • HIV Treatment: Used as part of combination therapy to manage HIV infection and reduce the risk of developing acquired immunodeficiency syndrome (AIDS).
  • Chronic Hepatitis B: Used to manage chronic hepatitis B to reduce viral load and liver damage.

• Route: Oral.
• Dosage: Typically, the standard dosage is one 300 mg tablet once daily. However, dosage may vary based on the patient's condition and response to treatment.

• Gastrointestinal: Nausea, diarrhea, abdominal pain.
• General: Fatigue, headache.
• Renal: Possible kidney issues, which might require regular monitoring.
• Bone: Potential for decreased bone mineral density.
• Other: Rash, dizziness, or muscle pain.

• Kidney Function: Regular monitoring of kidney function is important, as tenofovir can affect renal health.
• Bone Health: Monitoring for bone density issues may be recommended, especially in long-term use.
• HIV Resistance: This medication should be used in combination with other antiretroviral agents to prevent the development of drug-resistant strains of HIV.
• Interactions: Inform your healthcare provider about all other medications you are taking, including over-the-counter drugs and supplements, as tenofovir can interact with other drugs.

• Consistency: Take the medication at the same time each day to maintain even levels in the bloodstream.
• Food: Tenofovir can be taken with or without food. However, taking it with food may help reduce gastrointestinal side effects.

• Adherence: It’s crucial to adhere to the prescribed regimen to effectively manage HIV or hepatitis B and to prevent the development of drug resistance.
• Monitoring: Regular follow-up appointments are essential to monitor the effectiveness of the treatment and manage any potential side effects.

Voriconazole Tablets IP are an antifungal medication used to treat a variety of fungal infections. Here’s a detailed overview:

• Composition: Voriconazole tablets typically come in various strengths, such as 50 mg or 200 mg. The "IP" designation indicates that the formulation meets the standards set by the Indian Pharmacopoeia.

• Indication: Voriconazole is used to treat:

  • Invasive Aspergillosis: A serious fungal infection caused by Aspergillus species.
  • Candidemia: Fungal infection caused by Candida species, particularly in non-neutropenic patients.
  • Other Invasive Fungal Infections: Including those caused by Fusarium species and Scedosporium apiospermum.

• Mechanism of Action: Voriconazole works by inhibiting the synthesis of ergosterol, an essential component of the fungal cell membrane. This disruption impairs fungal cell membrane integrity and function, leading to the death of the fungal cells.

• Administration: Voriconazole is taken orally in tablet form. The usual dosing regimen varies depending on the specific infection being treated, the patient's condition, and their response to the medication. For example, the typical starting dose for invasive fungal infections might be 400 mg twice daily for the first 24 hours, followed by 200 mg twice daily.

• Side Effects: Common side effects include nausea, vomiting, diarrhea, liver enzyme abnormalities, rash, and visual disturbances (such as blurred vision or color changes). More severe side effects may include liver toxicity, hallucinations, and severe allergic reactions.

• Precautions: Regular monitoring of liver function is important during treatment, as voriconazole can affect liver enzyme levels. It is also important to be cautious about potential interactions with other medications, as voriconazole can affect the metabolism of various drugs. Patients should avoid excessive sun exposure, as voriconazole can increase sensitivity to sunlight.

• Drug Interactions: Voriconazole can interact with numerous other medications, potentially altering their effectiveness or increasing the risk of side effects. It's important to inform your healthcare provider about all other medications and supplements you are taking.

Dasatinib 70 mg Tablet is an oral medication used primarily in the treatment of certain types of cancer, specifically chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) that are Philadelphia chromosome-positive (Ph+). Dasatinib is a type of drug known as a tyrosine kinase inhibitor (TKI), which works by blocking the action of an abnormal protein that signals cancer cells to multiply.

• Chronic Myeloid Leukemia (CML): Dasatinib is used for the treatment of CML in chronic, accelerated, or blast phase, particularly in patients who are newly diagnosed or have resistance or intolerance to prior therapies, including imatinib.
• Acute Lymphoblastic Leukemia (ALL): Specifically, it is used for Philadelphia chromosome-positive (Ph+) ALL in patients who have failed prior therapy.

• 70 mg Dose: The specific dosage may vary based on the phase of CML or the condition being treated. In some cases, dasatinib may be administered once or twice daily.
• Administration: Tablets should be swallowed whole, not crushed or chewed, and can be taken with or without food. Consistent timing of doses is recommended to maintain stable drug levels in the body.

• Common Side Effects: These can include fluid retention (edema), pleural effusion (fluid around the lungs), diarrhea, headache, fatigue, rash, nausea, and musculoskeletal pain.
• Serious Side Effects: May include severe fluid retention, myelosuppression (low blood cell counts), bleeding, heart problems (such as heart failure or arrhythmias), pulmonary arterial hypertension, and liver dysfunction.
• Myelosuppression: Regular blood tests are necessary to monitor blood cell counts, as dasatinib can cause low levels of red blood cells, white blood cells, and platelets.

• Regular Monitoring: Patients on dasatinib require regular monitoring of blood counts, liver function, and cardiac function.
• Fluid Retention: Signs of fluid retention, including swelling, rapid weight gain, or shortness of breath, should be reported to a healthcare provider immediately.
• Drug Interactions: Dasatinib can interact with other medications, particularly those that affect the liver enzyme CYP3A4. It's important to inform healthcare providers of all medications being taken.

• Pregnancy: Dasatinib should not be used during pregnancy due to potential harm to the fetus. Effective contraception is recommended during treatment.
• Dietary Restrictions: Grapefruit and grapefruit juice should be avoided as they can increase the levels of dasatinib in the blood, potentially leading to increased side effects.

Enzalutamide is a medication used primarily to treat prostate cancer. The "Enzalutamide Tablets 160 mg" indicates that each tablet contains 160 milligrams of enzalutamide.

Here’s a brief overview:

• Form: Oral tablets.
• Dosage: 160 mg per tablet.
• Use: Enzalutamide is commonly prescribed for the treatment of metastatic castration-resistant prostate cancer (mCRPC) and, in some cases, for non-metastatic castration-resistant prostate cancer (nmCRPC) as per the healthcare provider's guidance.

Administration:

• Enzalutamide is taken orally, usually once daily. The tablets should be swallowed whole with water, and should not be crushed or chewed.

Common Side Effects:

• Fatigue
• Hot flashes
• Diarrhea
• Nausea
• Joint pain
• High blood pressure
• Risk of falls or fractures
• Potential for seizures

Precautions:

• Regular monitoring is necessary to assess for side effects and adjust treatment if needed.
• Inform your healthcare provider about any other medications you are taking, as enzalutamide can interact with other drugs.
• Be aware of serious side effects such as symptoms of a seizure, severe allergic reactions, or significant changes in mood.

Voriconazole is an antifungal medication used to treat serious fungal infections. The "Voriconazole Tablets IP 200 mg" indicates that each tablet contains 200 milligrams of voriconazole and conforms to the standards set by the Indian Pharmacopoeia (IP).

• Form: Oral tablets.
• Dosage: 200 mg per tablet.
• Use: Voriconazole is used to treat a variety of fungal infections, including:
  • Aspergillosis: A serious infection caused by Aspergillus species.
  • Candidemia: A bloodstream infection caused by Candida species.
  • Coccidioidomycosis: Caused by Coccidioides fungi.
  • Cryptococcal meningitis: Particularly in HIV-positive patients.
  • Other invasive fungal infections: Sometimes used for other severe fungal infections as determined by a healthcare provider.

• Route: Oral.
• Dosage: Typically, voriconazole is started with a loading dose and then followed by a maintenance dose. The exact dosing regimen can vary based on the infection being treated and the patient’s condition.

• Gastrointestinal: Nausea, vomiting, diarrhea.
• Neurological: Headache, dizziness, visual disturbances (including blurred vision and altered color perception).
• Skin: Rash, itching.
• Liver: Elevated liver enzymes or liver dysfunction.

• Liver Function: Regular monitoring of liver function may be necessary, as voriconazole can affect the liver.
• Visual Disturbances: Be cautious of potential visual disturbances, which can occur with this medication.
• Drug Interactions: Voriconazole can interact with a variety of other medications. Inform your healthcare provider about all other medications you are taking, including over-the-counter drugs and supplements.
• Kidney Function: Some adjustments may be needed in cases of renal impairment.

• Consistency: Take the medication at the same time each day to maintain even levels in the bloodstream.
• Food: Voriconazole can be taken with or without food. However, taking it with food might reduce gastrointestinal side effects.

• Adherence: It’s important to complete the full course of voriconazole as prescribed, even if symptoms improve before finishing the medication.
• Monitoring: Regular follow-up appointments may be required to monitor the effectiveness of the treatment and manage any potential side effects.

Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate Tablets IP are a combination antiretroviral medication used for the treatment of HIV-1 infection. This combination is effective in reducing the viral load and increasing CD4 cell counts in HIV-infected individuals.

• Generic Names: Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate
• Form: Tablet
• Administration Route: Oral

• Treatment of HIV-1 infection in adults and adolescents aged 12 years and older.
• Can be used as part of antiretroviral therapy (ART) for patients who are antiretroviral-naive or have no known resistance to any of the three components.

Each component of the combination tablet works in a different way to inhibit HIV replication:

1. Efavirenz: A non-nucleoside reverse transcriptase inhibitor (NNRTI) that binds to reverse transcriptase, blocking the RNA-dependent and DNA-dependent DNA polymerase activities, including HIV-1 replication.
2. Emtricitabine: A nucleoside reverse transcriptase inhibitor (NRTI) that inhibits the activity of HIV-1 reverse transcriptase by being incorporated into viral DNA, causing chain termination.
3. Tenofovir Disoproxil Fumarate: A nucleotide reverse transcriptase inhibitor (NtRTI) that, once converted to its active form, inhibits the activity of HIV-1 reverse transcriptase by being incorporated into viral DNA, causing chain termination.

Sofosbuvir and Velpatasvir are antiviral medications used in combination to treat chronic hepatitis C virus (HCV) infection. This combination therapy is effective against multiple genotypes of HCV and is typically used to cure the infection.

Sofosbuvir is a nucleotide analog polymerase inhibitor that works by blocking the HCV enzyme NS5B, which is crucial for viral replication.

Velpatasvir is an NS5A inhibitor that interferes with the NS5A protein, which is also essential for the replication of the virus.